PUBLICATIONS
2024:
Kang, D. D., Hou, X., Wang, L., Xue, Y., Li, H., Zhong, Y., Wang, S., Deng, B., McComb, D., & Dong, Y*, Engineering LNPs with polysarcosine lipids for mRNA delivery. Bioactive Materials, 37, 86-93 (2024).
Xue, Y., Zhang, Y., Zhong, Y., Du, S., Hou, X., Li, W., Li, H., Wang, S., Wang, C., Yan, J., Kang, D. D., Deng, B., McComb, D. W., Irvine, D. J., Weiss, R., Dong, Y.*, LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing. Nature Communications, 15 (1), 739 (2024). PMID: 38272900
2023:
- Swanda, R., Ji, Q., Wu, X., Yan, J., Dong, L., Mao, Y., Uematsu, S., Dong, Y., Qian S.*, Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response, Molecular Cell, 83, 18, 3347-3359 (2023). PMID: 37647899
- Chen, S., Huang, X., Xue, Y., Benedicto, E., Shi, Y., Chen, W., Koo, S., Sigeward, D.*, Dong, Y.*, Tao, W.*, Nanotechnology-based mRNA vaccines, Nature Reviews Methods Primers, 3, 63, (2023).
- Zhang, Y., Hou, X., Du, S., Xue, Y., Yan, J., Kang, D., Zhong, Y., Wang, C., Deng, B., McComb, D., Dong, Y.*, Close the cancer–immunity cycle by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy, Nature Nanotechnology, (2023). PMID: 37500773
- Cui, Z., Wang, H., Dong, Y.*, Liu, S.* Wang, Q.*, Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches, Frontiers in Genome Editing, 13, 5, 1231656 (2023). PMID: 37520399
- Wang, C., Wang, S., Kang, D., Dong, Y.*, Biomaterials for in situ cell therapy, BMEMat, 1(3), e12039 (2023).
- Du, S., Yan, J., Xue, Y., Zhong, Y., Dong, Y.*, Adoptive cell therapy for cancer treatment, Exploration, 3, 20210058 (2023).
- Kang, D., Li, H., Dong, Y.*, Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics, Advanced Drug Delivery Reviews, 199, 114961 (2023). PMID: 37321375
- Bohmer, M., Xue, Y., Jankovic, K., Dong, Y.*, Advances in engineering and delivery strategies for cytokine immunotherapy, Expert Opinion on Drug Delivery, 20, 5, 579-595 (2023). PMID: 37104673
- Zhang, Y., Yan, J., Hou, X., Wang, C., Kang, D., Xue, Y., Du, S., Deng, B., McComb, D., Liu, S., Zhong, Y., Dong, Y.*, STING Agonist-Derived LNP-mRNA Vaccine Enhances Protective Immunity Against SARS-CoV-2, Nano letter, 23, 7, 2593–2600 (2023). PMID: 36942873
- Zhong, Y., Du, Shi., Dong, Y.*, mRNA delivery in cancer immunotherapy, Acta Pharmaceutica Sinica B, 13-4, 1348-1357 (2023). PMID: 37139419
- Du, S., Zhang, Y., Li, W., Xue, Y., Hou, X., Yan, J., Cheng, J., Deng, B., McComb, D., Lin, J., Zeng, H., Cheng, X., Irvine, D., Weiss, R., Dong, Y.*, Cholesterol-Amino-Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self-Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice, Advanced Science, 10(11):e2300188 (2023). PMID: 36748274
- Kim, B., Hosn, R., Remba, T., Yun, D., Li, N., Abraham, W., Melo, M., Cortes, M., Li, B., Zhang, Y., Dong, Y., Irvine, D.*, Optimization of storage conditions for lipid nanoparticle-formulated self-replicating RNA vaccines, Journal of Controlled Releases, 353, 241-253 (2023). PMID: 36414195
2022:
- Yan, J., Zhang, Y., Du, S., Xu, C., Li, W., Zhao, Y., Zeng, C., Zhang, C., Cheng, J., Deng, B., McComb, D., Zhao, W., Xue, Y., Kang, D., Cheng, X., Dong, Y.*, Nanomaterials Mediated Co-Stimulation of toll-like Receptors and CD40 for Antitumor Immunity, Advanced Materials, 34-2207486, (2022). PMID: 36121735
- Cui, Z., Zeng, C., Huang, F., Yuan, F., Yan, J., Zhao, Y., Zhou, Y., Hankey, W., Jin, V., Huang, J., Staats, H., Everitt, J., Sempowski, G., Wang, Hong., Dong, Y.*, Liu, S.*, Wang, Q.*, Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection, Nature Chemical Biology, 18-1056 (2022). PMID: 35879545
- Hu, A., Zhu, J., Zeng, C., Lin, C., Yu, J., Liu, J., Lynch, K., Talebian, F., Pan, X., Yan, J., Dong, Y., Li, Z., Bai, X.*, IL-27 Induces CCL5 Production by T Lymphocytes, Which Contributes to Antitumor Activity, The Journal of Immunology, 9-208 (2022). PMID: 35418466
- Liu, J., Zhang, C., Zhang, X., Yan, J., Zeng, C., Talebian, F., Lynch, K., Zhao, W., Hou, X., Du, S., Kang, D., Deng, B., McComb, D., Bai, X.*, Dong, Y.*, Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy, Journal of Controlled Release, 345-306 (2022). PMID: 35301053
- Dong, Y.*, Anderson, D.*, Opportunities and Challenges in mRNA Therapeutics, Accounts of Chemical Research, 1c00739 (2022). PMID: 34979806
- Hong, F.*, Lin, C., Yan, J., Dong, Y., Ouyang, Y., Kim, D., Zhang, X., Liu, B., Sun, S., Gu, W., Li, Z.*, CNPY2 Contributes to Liver Oncogenesis by Promoting UPR-dependent destabilization of p53, Hepatology, 76-1658 (2022). PMID: 34986508
2021:
- Xue, Y., Baig, R., Dong, Y.*, Recent advances of biomaterials in stem cell therapies, Nanotechnology, 33-132501 (2021). PMID: 34933291
- Li, W., Zhang, X., Zhang, C., Yan, J., Hou, X., Du, S., Zeng, C., Zhao, W., Deng, B., McComb, D., Zhang, Y., Kang, D., Li, J., Carson, W., Dong, Y.*, Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy, Nature Communications, 12-7264 (2021). PMID: 34907171
- Wang, C., Zhang, Y., Dong, Y.*, Lipid Nanoparticle–mRNA Formulations for Therapeutic Applications, Accounts of Chemical Research, 1c00550 (2021). PMID: 34793124
- Yan, J., Kang, D., Turnbull, G., Dong, Y.*, Delivery of CRISPR-Cas9 system for screening and editing RNA binding proteins in cancer, Advanced Drug Delivery Reviews, 114042 (2021). PMID: 34767864
- Zhao, W., Zeng, C., Yan, J., Shi, D., Hou, X., Zhang, C., Li, W., Deng, B., McComb, D., Xue, Y., Kang, D., Dong, Y.*, Construction of Messenger RNA (mRNA) Probes Delivered By Lipid Nanoparticles to Visualize Intracellular Protein Expression and Localization at Organelles, Advanced Materials, 2103131 (2021). PMID: 34541724
- Hou, X., Zaks, T.*, Langer, R.*, Dong, Y.*, Lipid nanoparticles for mRNA delivery, Nature Reviews Materials, 6, 1078–1094 (2021). PMID: 34394960
- Zhang, Y., Sun, C., Wang, C., Jankovic, K., Dong, Y.*, Lipids and Lipid Derivatives for RNA Delivery, Chemical Reviews, 121, 12181–12277 (2021). PMID: 34279087
- Yan, J., Kang, D., Dong, Y.*, Harnessing lipid nanoparticles for efficient CRISPR delivery, Biomaterials Science, 06-11 (2021). PMID: 34115079
- Zeng, C., Hou, X., Bohmer, M., Dong, Y.*, Advances of nanomaterials-based strategies for fighting against COVID-19, View, 20200180 (2021). PMID: 34766161
- Chan, C., Du, S., Dong, Y.*, Cheng, X*., Computational and Experimental Approaches to Investigate Lipid Nanoparticles as Drug and Gene Delivery Systems, Current Topics in Medicinal Chemistry, 21(2):92-114 (2021). PMID: 33243123
2020:
- Zhang, S., Shrestha, C., Wisniewski, B., Pham, H., Hou, X., Li, W., Dong, Y., Kopp, B*., Consequences of CRISPR-Cas9-Mediated CFTR Knockout in Human Macrophages, Frontiers in Immunology,11:1871 (2020). PMID: 32973772
- Zeng, C., Hou, X., Yan, J., Zhang, C., Li, W., Zhao, W., Du, S., Dong, Y.*, Leveraging mRNA Sequences and Nanoparticles to Deliver SARS-CoV-2 Antigens In Vivo, Advanced Materials, 2004452 (2020). PMID: 32875709
- Zhang, X., Zhao, W., Nguyen, G., Zhang, C., Zeng, C., Yan, J., Du, S., Hou, X., Li, W., Jiang, J., Deng, B., McComb, D., Dorkin, R., Shah, A., Barrera, L., Gregoire, F., Sign, M., Chen, D*., Sabatino, D*., Dong, Y.*, Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing, Science Advances, 6.34 (2020). PMID: 32937374
- Li, Y., Su, Z., Zhao, W., Zhang, X., Momin, N., Zhang, C., Wittrup, K., Dong, Y.*, Irvine, D*., Weiss, R*.,Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity, Nature Cancer, 10.1038 (2020). PMID: 34447945
- Zeng, C., Zhang, C., Walker, P., Dong, Y.*, Formulation and Delivery Technologies for mRNA Vaccines, Current Topics in Microbiology and Immunology, 10.1007 (2020). PMID: 32483657
- Zhao, P., Zhang, Y., Li, W., Jeanty, C., Xiang, G*., Dong, Y.*, Recent advances of antibody drug conjugates for clinical applications, Acta Pharmaceutica Sinica B, 04-012 (2020). PMID: 33088681
- Zhao, P., Hou, X., Yan, J., Du, S., Xue, Y., Li, W., Xiang, G.*, Dong, Y.*, Long-term storage of lipid-like nanoparticles for mRNA delivery, Bioactive Materials, 5 (2): 358-363 (2020). PMID: 32206737
- Li, W., Chan, C., Zeng, C., Turk, R., Behlike, M., Cheng, X*., Dong, Y.*, Rational Design of Small Molecules to Enhance Genome Editing Efficiency by Selectively Targeting Distinct Functional States of CRISPR-Cas12a, Bioconjugate Chemistry, 18:31(3):542-546 (2020). PMID: 32119776
- Guo, S., Vieweger, M., Zhang, K., Yin H., Wang, H., Li, X., Li, S., Hu, S., Sparreboom, A., Evers, B., Dong, Y., Chiu, W., Guo, P.*,Ultra-thermostable RNA Nanoparticles for Solubilizing and High-yield Loading of Paclitaxelfor Breast Cancer Therapy, Nature Communication, 11:972 (2020). PMID: 32080195
- Li, B., Yan, J., Zhang, Y., Li, W., Zeng, C., Zhao, W., Hou, X., Zhang, C., Dong, Y.*, CRISPR-Cas12a Possess Unconventional DNase Activity that Can Be Inactivated by Synthetic Oligonucleotides, Molecular Therapy-Nucleic Acids, 19:1043-1052 (2020). PMID: 32045875
- Hou, X., Zhang, X., Zhao, W., Zeng, C., Deng, B., McComb, D. W., Du, S., Zhang, C., Li. W., Dong, Y.*, Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis, Nature Nanotechnology, 15(1):41-46 (2020). PMID: 31907443
2019:
- Li, B*., Niu, Y*., Ji, W*., Dong, Y.*, Strategies for the CRISPR-based therapeutics, Trends in Pharmacological Sciences, 41(1):55-65 (2019). PMID: 31862124
- Zhao, W., Hou, X., Vick, O.G., Dong, Y.*,RNA delivery biomaterials for the treatment of genetic and rare diseases, Biomaterials, 217:119291 (2019). PMID: 31255978
- Dong, Y., Siegwart, D. J., Anderson, D.G., Strategies, design, and chemistry in siRNA delivery systems, Advanced drug delivery reviews, 144:133-147 (2019). PMID: 31102606
- Zhang, Y., Zhang, X., Zeng, C., Li, B., Zhang, C., Li, W., Hou, X., Dong, Y.*, Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR), Bioorganic & medicinal chemistry, 27(11): 2187-2191 (2019). PMID: 31005367
- Zhang, C., Zhao, W., Bian, C., Hou, X., Deng, B., McComb, D. W., Chen, X., Dong, Y.*, Antibiotic-derived lipid nanoparticles to treat intracellular Staphylococcus aureus, ACS Appl. Bio Mater., 2(3): 1270-1277 (2019). PMID: 31750420
- Zhang, C., Zhang, X., Zhao, W., Zeng, C., Li, W., Li, B., Luo, X., Li, J., Jiang, J., Deng, B., McComb, D. W., Dong, Y.*, Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer, Nano Research, 12(4):855-861 (2019). PMID: 31737223
2018:
- Zhang, X., Zhang, C., Yang, X., Hou, X., Zhao, W., Benson, D., Yu, J., Dong, Y.*, Design, synthesis and evaluation of anti-CD38 antibody drugconjugate based on Daratumumab and Maytansinoid, Bioorganic & Medicinal Chemistry, 27(3):479-482 (2018). PMID: 30594452
- Li, B., Zeng, C., Li, W., Zhang, X., Luo, X., Zhao, W., Zhang, C., Dong, Y.*, Synthetic oligonucleotides inhibit CRISPR-Cpf1- mediated genome editing, Cell Reports, 25(12):3262-3272 (2018). PMID: 30566855
- Zhang, X., Zhao, W., Li, B., Li, W., Zhang, C., Hou, X., Jiang, J., Dong, Y.*, Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice, Chemical Science, 9(43):8207-8212 (2018). PMID: 30542568 (HOT Chemical Science articles for September)
- Zhao, W., Zhang, C., Li, B., Zhang, X., Luo, X., Zeng, C.,Li, W., Gao, M., Dong, Y.*, Lipid polymer hybrid nanomaterials for mRNA delivery, Cellular and Molecular Bioengineering, 11(5):397-406 (2018). PMID: 30555598
- Luo, X., Zhao, W., Li, B., Zhang, C., Bratasz, A., Deng, B., McComb, D. W., Dong, Y.*, Co-delivery of mRNA and SPIONs through amino-ester nanomaterials, Nano Research, 11(10):5596-5603 (2018).
- Li, B., Zhang, X., Dong, Y.*, Nanoscale platforms for messenger RNA delivery, Wiley Interdiscip Rev Nanomed Nanobiotechnol, e1530. PMID: 29726120
- Li, B., Zeng, C., Dong, Y.*, Design and assessment of engineered CRISPR– Cpf1 and its use for genome editing, Nature Protocols, 13(5):899–914 (2018). PMID: 28840077
2017:
- Guo, S., Li, H., Ma, M., Fu, J., Dong, Y.*, Guo, P*., Size, shape, and sequence-dependent immunogenicity of RNA nanoparticles, Molecular Therapy: Nucleic Acids, 9:399-408 (2017). PMID: 5701797
- Zhang, X., Chen, X., Zhao, W., Zeng, C., Luo, X., Li, W., Li, B., Jiang, J., Dong, Y.*,GlcNAc conjugated atorvastatin with enhanced water solubility and cellular internalization, Bioconjugate Chem, 28(8):2109-2113 (2017). PMID: 28745862
- Zhang, X.,1 Li, B.,1 Luo, X.,1 Zhao, W., Jiang, J., Zhang, C., Gao, M., Chen, X., Dong, Y.*, Biodegradable amino-ester nanomaterials for Cas9 mRNA delivery in vitro and in vivo, ACS Appl. Mater. Interfaces, 9(30):25481-25487 (2017). PMID: 28685575
- Li, B., Zhao, W., Luo, X., Zhang, X., Li, C., Zeng, C., Dong, Y.*, Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency, Nature Biomedical Engineering, 1(5): (2017). PMID: 28840077
- Jiang, C.,1 Mei, M.,1 Li, B.,1 Zhu, X.,1 Zu, W., Tian, Y., Wang, Q., Guo, Y., Dong, Y.*,Tan, X.* A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo, Cell Research, 27(3):440-443 (2017). PMID: 28117345
- Luo, X., Li, B., Zhang, X., Zhao, W., Bratasz, A., Deng, B., McComb, D. W., Dong, Y.*, Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents, Nanoscale, 9(4):1575-1579 (2017). PMID: 28067926
- Luo, X., Wang, W., Dorkin, J. R., Veiseh, O., Chang, P. H., Abutbul-Ionita, I., Danino, D., Langer, R., Anderson, D. G.*,Dong, Y.*, Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo, Biomaterials Science, 5(1):38-40 (2017). PMID: 27921096
2016:
- Li, B.,1 Zhao, W.,1 Zhang, X.,1 Wang, J., Luo, X., Baker, S. D., Jordan, C. T., Dong, Y.*, Design, synthesis and evaluation of anti-CD123 antibody drug conjugates, Bioorganic & Medicinal Chemistry, 24(22):5855-5860 (2016). PMID: 27687970
- Dong, Y., Wang, W., Veiseh, O., Appel, E. A., Xue, K., Webber, M. J., Tang, B., Yang, X. W., Weir, G., Langer, R., Anderson, D. G. Injectable and glucose-responsive hydrogels based on boronic acid–glucose complexation, Langmuir, 21(34):8743-8747 (2016). PMID: 27455412
- Wang, J., Li, B., Zhao, W., Zhang, X., Luo, X., Corkins, M. E., Cole, S. L., Wang, C., Xiao, Y., Bi, X., Pang, Y., McElroy, C. A., Bird, A. J., Dong, Y.*, Two-photon near infrared (NIR-NIR) fluorescent turn-on probe toward cysteine (Cys) and its imaging applications, ACS Sensor, 1(7):882-887 (2016).
- Li, B., Luo, X., Dong, Y.*, Effects of chemically modified messenger RNA on protein expression, Bioconjugate Chemistry, 27(3):849-853 (2016). PMID:2690652
- Li, B.,1 Luo, X.,1 Deng, B., Giancola, D. W., McComb, D. W., Schmittgen, T. D., Dong, Y.*, Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA, Scientific Reports, doi: 10.1038/srep22137 (2016). PMID: 26916931
- Yin, H., Song, C.-Q., Dorkin, R. J., Zhu, L., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., Gupta, A., Bolukbasi, M. F., Walsh, S., Bogorad, R. L., Gao, G., Weng, Z., Dong, Y., Kotelianski, V., Wolfe, S. A., Langer, R., Xue, W., Anderson, D. G. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Nature Biotechnology, 34(3):328-333 (2016). PMID: 26829318
- Dong, Y., Dorkin, R. J., Wang, W., Chang, P. H., Webber, M. J., Tang, B. C., Yang, J., Abutbul-Ionita, I., Danino, D., DeRosa, F., Heartlein, M., Langer, R., Anderson, D.G. Poly(glycoamidoamine) brushes formulated nanomaterials for systemic siRNA and mRNA deliveryin Vivo, Nano Letters, 16(2):842-848 (2016). PMID: 26727632
2015:
- Li, B., Luo. X., Deng, B., Wang, J., McComb, D., Shi, Y., Gaensler, K., Tan, X., Dunn, A., Kerlin, B., Dong, Y.*, An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo, Nano Letters, 15(12):8099-8107 (2015). PMID: 26529392
- Khan, O. F., Zaia, E. W., Jhunjhunwala, S., Xue, W., Cai, W., Yun, D. S., Barnes, C., Dahlman, J. E., Dong, Y., Pelet, J. M., Webber, M. J., Tsosie, J., Jacks, T., Langer, R., Anderson, D. G. Dendrimer-inspired nanomaterials for the in vivodelivery of siRNA to lung vasculature, Nano Letters, 15(5):3008-3016 (2015). PMID: 25789998
2014 and Prior:
- Dong, Y.; Eltoukhy, A. A.; Alabi, C. A.; Kohan, O. F.; Veiseh, O.; Dorkin, R. J.; Sirirungruang, S.; Yin, H.; Tang, B. C.; Pelet, J.; Chen, D.; Gu, Z.; Xue, Y.; Langer, R.; Anderson, D. G. Lipid like Nanomaterials for Simultaneous Gene Silencing and Expressionin vivo, Advanced Healthcare Materials, 3 (9) 1392-1397 (2014). PMID: 24623658
- Dong, Y.; Love, K. T.; Dorkin, R. J.; Sirirungruang, S.; Zhang, Y.; Chen, D.; Bogorad, R., Yin, H., Chen, Y; Vegas, A.; Alabi, C. A.; Sahay, G., Olejnik, K. T.; Wang, W.; Shroeder, A.; Lytton-Jean, A. K. R.; Siegwart, D. J.; Akinc, A.; Barnes, C., Barros, S. A.; Carioto, M.; Fitzgerald, K.; Hettinger, J.; Kumar, V.; Novobrantseva, T. I.; Qin, J.; Querbers, W.; Kotelianski, V.; Langer, R.; Anderson, D. G. Lipopeptide Nanoparticles for Potent and Selective siRNA Delivery in Rodents and Nonhuman Primates, Proceedings of the National Academy of Sciences, 111 (11), 3955-3960 (2014). PMID: 24516150 (Highlighted by SciBX, 2014).
- Dahlman, J. E.; Barnes, C.; Khan, O. F.; Thiriot, A.; Jhunjunwala, S.; Shaw, T. E.; Xing, Y.; Sager, H. B.; Sahay, G.; Speciner, L.; Bader, A.; Bogorad, R. L.; Yin, H.; Racie, T.; Dong, Y.; Jiang, S.; Seedorf, D.; Dave, A.; Singh Sandhu, K.; Webber, M. J.; Novobrantseva, T.; Ruda, V. M.; Lytton-JeanAbigail, K. R.; Levins, C. G.; Kalish, B.; Mudge, D. K.; Perez, M.; Abezgauz, L.; Dutta, P.; Smith, L.; Charisse, K.; Kieran, M. W.; Fitzgerald, K.; Nahrendorf, M.; Danino, D.; Tuder, R. M.; von Andrian, U. H.; Akinc, A.; Panigrahy, D.; Schroeder, A.; Koteliansky, V.; Langer R.; Anderson, D. G. In vivoendothelial siRNA delivery using polymeric nanoparticles with low molecular weight, Nature Nanotechnology, 9 (8), 648-655 (2014). PMID: 24813696
- Eltoukhy, A. A.; Chen, D.; Veiseh, O.; Pelet, J.; Yin, H.; Dong, Y.; Anderson, D. G. Nucleic Acid-Mediated Intracellular Protein Delivery by Lipid-like Nanoparticles, Biomaterials, 35 (24), 6454-6461 (2014). PMID: 24831975
- Gu, Z., Dang, T.T., Ma, M.M., Tang, B.C., Cheng, H., Jiang, S., Dong, Y., Zhang, Y., Anderson, D.G. Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery, ACS Nano, 7 (8), 6758-6766 (2013). PMID: 23834678
- Zhang, Y., Pelet, J.M., Heller, D.A., Dong, Y., Chen, D., Gu, Z., Joseph, B.J., Wallas, J., Anderson, D.G. Lipid-Modified Aminoglycoside Derivatives for in vivosiRNA Delivery, Advanced Materials, 33 (25) 4641–4645 (2013). PMID: 23813808
- Chen, D.; Love, K. T.; Chen, Y.; Eltoukhy, A. A.; Kastrup, C.; Dong, Y.; Whitehead, K. A.; Langer, R.; Anderson, D. G. Rapid Discovery of Potent siRNA-Lipid-Nanoparticles Enabled by Controlled Microfluidic Formulation, Journal of the American Chemical Society, 134 (16), 6948–6951 (2012). PMID: 22475086
- Wang, L-T., Pan, S-L., Chen, T-H., Dong, Y., Lee, K. H., Teng, C-M. DYZ-2-90, a Novel Neo-tanshinlactone Ring-Opened Compound, Induces ERK-Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells, ChemBioChem, 13 (11) 1663-1672 (2012). PMID: 22761044
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Yoon, K.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, E. Y.-H.; Lee, K. H. Antitumor Agents 289. Design, Synthesis, and In VivoAnti-Breast Cancer Activity of 4-Amino-2H-benzo[h]chromen-2-one (ABO) and 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (ATBO) Analogs with Improved Water Solubility, Journal of Natural Products, 75 (3), 370–377 (2012). PMID: 22304236
- Lee, K. H.; Morris-Natschke, S. L.; Qian, K.; Dong, Y.; Yang, X.; Zhou, T.; Belding, E.; Wu, S. F.; Wada, K.; Akiyama, T. Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman’s Herbal Foundation Canon, Journal of Traditional and Complementary Medicine, 2, 6-26 (2012). PMID: 24716110
- Dong, Y.; Morris-Natschke, S. L.; Lee, K. H. Biosynthesis, Total Syntheses, and Antitumor Activity of Tanshinones and their Analogs as Potential Therapeutic Agents, Natural Product Reports, 28, 529-542 (2011). PMID: 21225077 (Selected and abstracted by ChemInform, 2011, 42, 27).
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, K. H. Antitumor Agents 287. Substituted 4-amino-2H-pyran-2-one (APO) Analogs Reveal a New Scaffold from Neo-tanshinlactone with In Vitro Anticancer Activity, Bioorganic & Medicinal Chemistry Letters, 21, 2341-2344 (2011). PMID: 21420855 (Selected and abstracted by ChemInform, 2011, 42, 34).
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, K. H. Antitumor Agents 281. Design, Synthesis, and Biological Activity of Substituted 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogs (ATBO) as Potent In Vitro Anticancer Agents, Bioorganic & Medicinal Chemistry Letters, 21, 546-549 (2011). PMID: 21087859
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Yoon, K.; Wu, P. C.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, E. Y.-H.; Lee, K. H. Antitumor Agents 279. Structure-Activity Relationship andIn Vivo Studies of Novel 2-(Furan-2-yl)naphthalen-1-ol (FNO) Analogs as Potent and Selective Anti-Breast Cancer Agents, Bioorganic & Medicinal Chemistry Letters, 21, 52-57 (2011). PMID: 21147529
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, K. H. Antitumor Agents 278. 4-Amino-2H-benzo[h]chromen-2-one Analogs (ABO) as Potent In Vitro Anticancer Agents, Bioorganic & Medicinal Chemistry Letters, 20, 4085-4087 (2010). PMID: 20542429
- Chou, L.-C.; Tsai, M.-T.; Hsu, M.-H.; Wang, S.-H.; Way, T.-D.; Huang, C.-H.; Lin, H.-Y.; Qian, K.; Dong, Y.; Lee, K.-H.; Huang, L.-J.; Kuo, S.-C. Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents, Journal of Medicinal Chemistry, 53, 8047-8058 (2010). PMID: 20973552
- Dong, Y.; Shi, Q.; Pai, H-C.; Peng, C-Y.; Pan, S-L.; Teng, C-M.; Nakagawa-Goto,K. ; Yu, D.;Liu, Y-N.; Wu, P-C.; Bastow, K.; Morris-Natschke, S. L.; Brossi, A.; Lang, J-Y.; Hsu, J. L.; Hung, M-C.; Lee, E. Y.-H. P. Lee, and Lee, K-H. Antitumor Agents 272. Structure–Activity Relationships andIn Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogs, Journal of Medicinal Chemistry, 53, 2299-2308 (2010). PMID: 20148565 (Highlighted by SciBX, February 25, 2010).
- Dong, Y.; Shi, Q.; Nakagawa-Goto,K. ; Wu, P. C.; Morris-Natschke, S. L.; Brossi, A.; Bastow, K.; Lee, K. H. Antitumor Agents 270. Novel Substituted 6-Phenyl-4H-furo[3,2-c]pyran-4-one Derivatives as Potent and Highly Selective Anti-Breast Cancer Agents, Journal of Medicinal Chemistry, 18, 803-808 (2010). PMID: 20034799 (Reported by NewsRX, Feb 22, 2010).
- Dong, Y.; Shi, Q.; Nakagawa-Goto,K. ; Wu, P. C.; Bastow, K.; Morris-Natschke, S. L.; Lee, K. H. Antitumor Agents 269. Non-Aromatic Ring-A Neo-tanshinlactone Analog, TNO, as a New Class of Potent Antitumor Agents, Bioorganic & Medicinal Chemistry Letters, 19, 6289-6292 (2009). PMID: 19819136 (Selected and abstracted by ChemInform , 2010 , 41, 12-203).
- Dong, Y.; Shi, Q.; Liu, Y. -N.; Wang, X.; Bastow, K.F.; Lee, K.-H. Antitumor Agents 266. Design, Synthesis, and Biological Evaluation of Novel 2-(Furan-2-yl)naphthalen-1-ol Derivatives as Potent and Selective Antibreast Cancer Agents, Journal of Medicinal Chemistry, 52, 3586-3590 (2009) (Highlighted by SciBX, May 21, 2009). PMID: 19425534
- 1.Zhong, Y. W.; Dong, Y.; Fang, K.; Izumi, K.; Xu, M. H.; Lin, G. Q. A Highly Efficient and Direct Approach for Synthesis of Enantiopure β-Amino Alcohols by Reductive Cross-Coupling of Chiral N-tert-Butanesulfinyl Imines with Aldehydes, Journal of the American Chemical Society, 127, 11956-11957 (2005). PMID: 16117531 (Highlighted by SYNFACTS , 2005, 3, 0331; Selected and abstracted by ChemInform , 2005, 37, 01-088).
*, corresponding author; 1, co-first author.
Selected Patents and Inventions (>40)
- Dong, Y.; Li, B. Lipid-like nanoparticles (LLN) and uses thereof, U.S. Provisional Patent application No 62/164,891, The Ohio State University, 2015.
- Dong, Y.; Wang, W.; Appel, E.A.; Veiseh, O.; Webber, M.J.; Tang, B.C.; Xue, K.;Langer, R.; Anderson, D. G. Injectable hydrogels and Uses Thereof, U.S. Provisional Patent application No. 62/137,003, 2015.
- Dong, Y.; Dorkin, R. J.; Langer, R.; Anderson, D. G. Polymer-Lipid Brush and Uses Thereof, U.S. Provisional Patent application No. 62/036,492, 2014.
- Dong, Y.; Anderson, D. G. Lipid formulations for delivery of messenger RNA, U.S. Patent application No. 14/521,161, 2014.
- Dong, Y.; Love, K. T.; Chen, D.; Chen, Y; Zhang, Y.; Vegas, A.; Alabi, C. A.; Langer, R.; Anderson, D. G. Amino acid-, Peptide- and Polypeptide-Lipids, Isomers, Compositions, and Uses Thereof, U.S. Patent application No. 13662002, 2013. (Filed in over 30 countries and regions; Licensed by two companies)
- Dong, Y.; Eltoukhy, A.A., Alabi, C. A.; Yin, H.; Dorkin, R. J.; Chen, D.; Langer, R.; Anderson, D. G. 1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof, U.S. Patent application No. 14267530, 2014.
- Anderson, D. G.; Chen, D.; Dong, Y.; Veiseh, O.; Eltoukhy, A.A.; Yin, H.; Langer, R.; Method for Achieving Intracellular Protein Delivery Using Oligonucleotide Conjugation and Uses Thereof, MIT – 16539, 2013.
- Anderson, D. G.; Dahlman, J. E.; Dong, Y.; Khan, O. F.; Langer, R.; Degradable and Non-Degradable Dendrimer-Based Lipidoids and Uses Thereof, MIT – 16054, 2013.
- Zhang, Y.; Heller, D. A.; Pelet, J.; Dong, Y.; Synthetic Sugar-based Lipids and Uses Thereof, MIT – 15369, 2012.
- Shroeder, A.; Dong, Y.; Stark, W. J.; a Water Treatment Device, MIT – 14856, 2011.
- Lee, K. H.; Dong, Y.; Bastow, K. Nakagawa-Goto,K.; Lee, E. Y.-H. 4-Amino-2H-pyran-2-one Analogs as Anticancer Agents; Patent No. WO 2012061012, 2012.
- Lee, K. H.; Dong, Y.; Shi, Q.; Bastow, K. Substituted FNO (2-(Furan-2-yl) naphthalen-1-ol) Derivatives as Anti-cancer Agents; Patent No. WO 2010080414, 2011.
- Lee, K. H.; Dong, Y.; Shi, Q.; Bastow, K.; Wu. P. C. Substituted AFPO (6-aryl-4H-furo [3,2-c]pyran-4-one) Derivatives as Anti-cancer Agents; Patent No. WO 2010080415, 2010.
- Lee, K. H.; Dong, Y.; Bastow, K. Nakagawa-Goto,K. Novel 4-amino-2H-benzo[h]chromen-2-one Analogs as Anti-Cancer agents; U.S. Provisional Patent application No. 61/317,983, 2010.
- Lee, K. H.; Dong, Y.; Shi, Q.; Bastow, K. Neo-tanshinlactone Analogs as Potent and Selective Anti-breast Cancer Agents; U.S. Provisional Patent application No. 61/243,731, 2009.
- Xu, M. H.; Lin, G. Q.; Zhong, Y. W.; Dong, Y. Process for Preparation of Chiral Amino Alcohols and Derivatives via Cross-coupling Reaction. Faming Zhuanli Shenqing Gongkai Shuomingshu (China Patent), 2005, CN1709865.