Welcome to Dong Research Group at Icahn School of Medicine at Mount Sinai
Our research is devoted to drug discovery and delivery for the treatment of genetic disorders, infectious diseases, and cancers. Together with our collaborators, we integrate our specialty in pharmaceutics, pharmaceutical chemistry, biomedical engineering, materials formulation, and animal studies to design novel therapeutic medicines and uncover their mechanisms of actions. The ultimate goal is to translate our scientific results and technological inventions into more effective treatments and more fulfilling lives of all individuals.
Dec 14, 2025– Yonger will start his research group at Shanghai Jiao Tong University. Congratulations to Prof. Xue!
Nov 26, 2025– Our work on peptibody mRNA is published on Nature Biotechnology. Congratulations to Yonger, Xucheng, and the collaborative teams!
Nov 25, 2024– Our collaborative Perspective with Dr. Eric Nestler is published on Nature Reviews Chemistry. Congratulations to Haoyuan, Changyue and Tami!
Nov 03, 2025– Dr. Shuang (Sammi) Wang and Dr. Xucheng Hou were awarded with the Junior Faculty Innovative Idea Prize at the 11th Annual Mount Sinai Innovation Awards.
Oct 24, 2025– Siyu will start his research group at Nanjing University of Posts and Telecommunications. Congratulations to Prof. Wang!
Oct 16, 2025– Our collaborative review article with the teams of Brian Brown and Abraham Teunissen is published on Nature Biomedical Engineering. Congratulations to Diana and the collaborative teams!
Oct 16, 2025– Our collaborative work with the team of Genentech is published on Materials today. Congratulations to Haoyuan, Yuebao, and the collaborative teams!
Aug 13, 2025– Our brain delivery paper is in press on Science Advances. Congratulations to Dinglingge, Xucheng, Chang, Siyu, and all co-authors!
Jul 15, 2025– Chang started his research group at The University of Oklahoma. Congratulations to Prof. Wang!
Jul 15, 2025– Yichen gave a poster presentation at the CRS 2025 Annual Meeting and Exposition.
Jul 14, 2025– Our collaborative review with Dr. Drew Weissman is published on Nature Reviews Drug Discovery. Congratulations to Siyu!
Apr 2, 2025– Diana successfully defended her dissertation thesis. Congratulations to Dr. Kang!
Mar 4, 2025– Our work on a new approach of cancer immunotherapy is published on Nature Communications. Congratulations to Yonger, Xucheng, Yichen, Yuebao and all the collaborators!
Feb 17, 2025– Our work on blood–brain barrier-crossing lipid nanoparticles (BLNP) is published on Nature Materials. Congratulations to Chang, Yonger, Tamara, and all the collaborators!
Xue, Y., Hou, X.*, Wang, S., Zhang, Y., Zhong, Y., Kang, D. D., Wang, C., Li, H., Yu, C., Liu, Z., Tian, M., Cao, D., Zheng, Y. Y., Deng, B., Hamon, P., Merad, M. , Dong, Y.*, Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia. Nature Biotechnology, (2025).
Li, H., Yu, C., Markovic, T., Nestler, E. J.*, Dong, Y.*, Chemical strategies for brain delivery of genomic therapy. Nature Reviews Chemistry, (2025).
GKang, D. D., Marks, A., Morla-Folch, J., Dong, Y.*, Brown, B. D.* , Teunissen, A. J. P.*, Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level. Nature Biomedical Engineering, (2025).
Cao, D., Hou, X., Wang, C., Wang, S., Liu, Z., Tian, M., Guo, K., Li, H., Kang, D. D., Zhong, Y., Xue, Y., Yu, C., Deng, B. , Dong, Y.*.Lipid nanoparticles for mRNA delivery in brain via systemic administration. Science Advances, (2025).
Wang, S., Weissman, D.*, Dong, Y.*. RNA chemistry and therapeutics. Nature Reviews Drug Discovery, (2025).
Wang, C., Xue, Y., Markovic, T., Li, H., Wang, S., Zhong, Y., Du, S., Zhang, Y., Hou, X., Yu, Y., Liu, Z., Tian, M., Kang, D. D., Wang, L., Guo, K., Cao, D., Yan, J., Deng, B., McComb, D. W., Parsons, R. E., Minier-Toribio, A. M., Holt, L. M., Pan, J., Hashemi, A., Kopell, B. H., Charney, A. W., Nestler, E. J.*, Peng, P. C.*, Dong, Y.*, Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nature Materials, (2025).
Wang, C., Wang, S., Xue, Y., Zhong, Y., Li, H., Hou, X., Kang, D. D., Liu, Z., Tian, M., Wang, L., Cao, D., Yu, Y., Liu, J., Cheng, X., Markovic, T., Hashemi, A., Kopell, B. H., Charney, A. W., Nestler, E. J.*, Dong, Y.*, Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system, Nature Biotechnology, (2025).
Wang, S., Zhang, Y., Zhong, Y., Xue, Y., Liu, Z., Wang, C., Kang, D. D., Li, H., Hou, X., Tian, M., Cao, D., Wang, L., Guo, K., Deng, B., McComb, D. W., Merad, M., Brown, B. D. , Dong, Y., Dong, Y.*, Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation. Proceedings of the National Academy of Sciences of the United States of America, (2024).
Zhang, Y., Hou, X., Du, S., Xue, Y., Yan, J., Kang, D. D., Zhong, Y., Wang, C., Deng, B., McComb, D. W., Dong, Y.*, Close the cancer–immunity cycle by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy, Nature Nanotechnology, (2023).
Hou, X., Zaks, T.*, Langer, R.*, Dong, Y.*, Lipid nanoparticles for mRNA delivery, Nature Reviews Materials, (2021).
Zhang, Y., Sun, C., Wang, C., Jankovic, K. E., Dong, Y.*, Lipids and Lipid Derivatives for RNA Delivery, Chemical Reviews, (2021).
Li, B., Zhao, W., Luo, X., Zhang, X., Li, C., Zeng, C., Dong, Y.*, Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency, Nature Biomedical Engineering, 1(5): (2017).
Address
Icahn Genomics Institute
Precision Immunology Institute
Department of Immunology and Immunotherapy
Department of Oncological Sciences
Tisch Cancer Institute
Friedman Brain Institute
Biomedical Engineering and Imaging Institute
Icahn School of Medicine at Mount Sinai
1425 Madison Avenue, New York, NY, 10029
Contact information
Email: yizhou.dong@mssm.edu
