Welcome to Dong Research Group at Icahn School of Medicine at Mount Sinai
Our research is devoted to drug discovery and delivery for the treatment of genetic disorders, infectious diseases, and cancers. Together with our collaborators, we integrate our specialty in pharmaceutics, pharmaceutical chemistry, biomedical engineering, materials formulation, and animal studies to design novel therapeutic medicines and uncover their mechanisms of actions. The ultimate goal is to translate our scientific results and technological inventions into more effective treatments and more fulfilling lives of all individuals.
Nov 25, 2024– Our work on blood–brain barrier-crossing conjugates (BCC) is published on Nature Biotechnology. Congratulations Chang, Siyu, and all the collaborators!
Oct 28, 2024– Yichen and Giang received the Trainee Innovation Idea Awards. Congratulations!
Aug 22, 2024– Diana helped organize the 2024 National Cancer Institute (NCI) Junior Investigator (JI) Meeting. Great job!
May 6, 2024– Our work on ROS-scavenging lipid nanoparticle is accepted by PNAS. Congratulations Siyu, Yuebao, Yichen, and all the contributors!
April 23, 2024– Xucheng is promoted to Assistant Professor. Congratulations Xucheng!
Mar 11, 2024– Our work on LNPs with polysarcosine lipids is accepted by Bioactive Materials. Congratulations Diana, Xucheng, and all the contributors!
Jan 15, 2024- Our work on stem cell engineering is accepted by Nature Communications. Congratulations Yonger, Yuebao, Yichen, and all the contributors!
Dec 12, 2023– Dr. Dong is inducted as a Fellow to the National Academy of Inventors. Congratulations!
Nov 13, 2023– Yonger successfully defended his dissertation thesis. Congratulations Dr. Xue!
Nov 02, 2023– Diana gave a research presentation at the NIH 2023 Synthetic Biology Consortium!
Sep 22, 2023– Xucheng presented our CATCH strategy for cancer immunotherapy at the 2023 PrIISM Retreat!
Jul 27, 2023– Our CATCH strategy for cancer immunotherapy is published on Nature Nanotechnology. Congratulations Yuebao, Xucheng, Shi, and all the contributors!
Jun 28, 2023– Our collaborative review article with the labs of Wei Tao and Daniel J. Siegwart is accepted by Nature Reviews Methods Primers. Congratulations to the collaborative teams!
Jun 10, 2023- “Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics”, an invited review is accepted by Advanced Drug Delivery Reviews. Congratulations Diana and Haoyuan!
Jun 5, 2023- “Adoptive cell therapy for cancer treatment”, an invited review is accepted by Exploration. Congratulations Shi, Jingyue, Yonger, and Yichen!
Apr 25, 2023- “Advances in engineering and delivery strategies for cytokine immunotherapy”, an invited review is accepted by Expert Opinion on Drug Delivery. Congratulations Margaret, Yonger and Katarina!
Mar 31, 2023- Jingyue successfully defended her dissertation thesis. Congratulations Dr. Yan!Mar 30, 2023- Shi successfully defended his dissertation thesis. Congratulations Dr. Du!
Mar 17, 2023– Our work on STING Agonist-Derived LNP-mRNA is accepted by Nano Letters. Congratulations Yuebao, Jingyue, Xucheng, and all the contributors!
Mar 09, 2023– “mRNA delivery in cancer immunotherapy”, an invited review is accepted by Acta Pharmaceutica Sinica B. Congratulations Yichen and Shi!
Wang, C., Wang, S., Xue, Y., Zhong, Y., Li, H., Hou, X., Kang, D.D., Liu, Z., Tian, M., Wang, L., Cao, D., Yu, Y., Liu, J., Cheng, X., Markovic, T., Hashemi, A., Kopell, B.H., Charney, A.W., Nestler, E.J., Dong, Y.*, Blood-brain barrier crossing conjugates (BCC) for the transport of biomacromolecules into the central nervous system via γ-secretase mediated transcytosis, Nature Biotechnology, in press.
Wang, S., Zhang, Y., Zhong, Y., Xue, Y., Liu, Z., Wang, C., Kang, D. D., Li, H., Hou, X., Tian, M., Cao, D., Wang, L., Guo, K., Deng, B., McComb, D. W., Merad, M., Brown, B. D., & Dong, Y.*, Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation. Proceedings of the National Academy of Sciences of the United States of America, 121(22), e2322935121 (2024).
Zhang, Y., Hou, X., Du, S., Xue, Y., Yan, J., Kang, D., Zhong, Y., Wang, C., Deng, B., McComb, D., Dong, Y.*, Close the cancer–immunity cycle by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy, Nature Nanotechnology, (2023).
Chen, S., Huang, X., Xue, Y., Benedicto, E., Shi, Y., Chen, W., Koo, S., Sigeward, D.*, Dong, Y.*, Tao, W.*, Nanotechnology-based mRNA vaccines, Nature Reviews Methods Primers, (2023).
Cui, Z., Zeng, C., Huang, F., Yuan, F., Yan, J., Zhao, Y., Zhou, Y., Hankey, W., Jin, V., Huang, J., Staats, H., Everitt, J., Sempowski, G., Wang, Hong., Dong, Y.*, Liu, S.*, Wang, Q.*, Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection, Nature Chemical Biology, 18-1056 (2022). PMID: 35879545
Dong, Y.*, Anderson, D.G.*, Opportunities and Challenges in mRNA Therapeutics, Accounts of Chemical Research, 1c00739 (2022). PMID: 34979806
Li, W., Zhang, X., Zhang, C., Yan, J., Hou, X., Du, S., Zeng, C., Zhao, W., Deng, B., McComb, D., Zhang, Y., Kang, D., Li, J., Carson, W., Dong, Y.*, Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy, Nature Communications, 12-7264 (2021). PMID: 34907171
Zhao, W., Zeng, C., Yan, J., Du, S., Hou, X., Zhang, C., Li, W., Deng, B., McComb, D.W., Xue, Y., Kang, D.D., Dong, Y.*, Construction of messenger RNA (mRNA) probes delivered by lipid nanoparticles to visualize intracellular protein expression and localization at organelles, Advanced Materials, 2103131 (2021). PMID: 34541724
Hou, X., Zaks, T.*, Langer, R.*, Dong, Y.*, Lipid nanoparticles for mRNA delivery, Nature Reviews Materials, (2021).
Zhang, Y., Sun, C., Wang, C., Jankovic, K., Dong, Y.*, Lipids and Lipid Derivatives for RNA Delivery, Chemical Reviews, (2021).
Li, Y., Su, Z., Zhao, W., Zhang, X., Momin, N., Zhang, C., Wittrup, K., Dong, Y.*, Irvine, D*., Weiss, R*., Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity, Nature Cancer, (2020).
Zhang, X., Zhao, W., Nguyen, G.N., Zhang, C., Zeng, C., Yan, J., Du, S., Hou, X., Li, W., Jiang, J., Deng, B., McComb, D. W., Dorkin, R., Shah, A., Barrera, L., Gregoire, F., Singh, M., Chen, D.*, Sabatino, D.E. *, Dong, Y.*, Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing, Science Advances, (2020).
Hou, X., Zhang, X., Zhao, W., Zeng, C., Deng, B., McComb, D. W., Du, S., Zhang, C., Li. W., Dong, Y.*, Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis, Nature Nanotechnology, (2020).
Zeng, C., Hou, X., Yan, J., Zhang, C., Li, W., Zhao, W., Du, S., Dong, Y.*, Leveraging mRNA Sequences and Nanoparticles to Deliver SARS-CoV-2 Antigens In Vivo, Advanced Materials, (2020).
Address
Icahn Genomics Institute
Precision Immunology Institute
Department of Immunology and Immunotherapy
Department of Oncological Sciences
Tisch Cancer Institute
Friedman Brain Institute
Icahn School of Medicine at Mount Sinai
1425 Madison Avenue, New York, NY, 10029
Contact information
Email: yizhou.dong@mssm.edu
