Welcome to Dong Research Group at Icahn School of Medicine at Mount Sinai
Our research is devoted to drug discovery and delivery for the treatment of genetic disorders, infectious diseases, and cancers. Together with our collaborators, we integrate our specialty in pharmaceutics, pharmaceutical chemistry, biomedical engineering, materials formulation, and animal studies to design novel therapeutic medicines and uncover their mechanisms of actions. The ultimate goal is to translate our scientific results and technological inventions into more effective treatments and more fulfilling lives of all individuals.
May 6, 2024– Our work on ROS-scavenging lipid nanoparticle is accepted by PNAS. Congratulations Siyu, Yuebao, Yichen, and all the contributors!
April 23, 2024– Xucheng is promoted to Assistant Professor. Congratulations Xucheng!
Mar 11, 2024– Our work on LNPs with polysarcosine lipids is accepted by Bioactive Materials. Congratulations Diana, Xucheng, and all the contributors!
Jan 15, 2024- Our work on stem cell engineering is accepted by Nature Communications. Congratulations Yonger, Yuebao, Yichen, and all the contributors!
Dec 12, 2023– Dr. Dong is inducted as a Fellow to the National Academy of Inventors. Congratulations!
Nov 13, 2023– Yonger successfully defended his dissertation thesis. Congratulations Dr. Xue!
Nov 02, 2023– Diana gave a research presentation at the NIH 2023 Synthetic Biology Consortium!
Sep 22, 2023– Xucheng presented our CATCH strategy for cancer immunotherapy at the 2023 PrIISM Retreat!
Jul 27, 2023– Our CATCH strategy for cancer immunotherapy is published on Nature Nanotechnology. Congratulations Yuebao, Xucheng, Shi, and all the contributors!
Jun 28, 2023– Our collaborative review article with the labs of Wei Tao and Daniel J. Siegwart is accepted by Nature Reviews Methods Primers. Congratulations to the collaborative teams!
Zhang, Y., Hou, X., Du, S., Xue, Y., Yan, J., Kang, D., Zhong, Y., Wang, C., Deng, B., McComb, D., Dong, Y.*, Close the cancer–immunity cycle by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy, Nature Nanotechnology, (2023).
Du, S., Zhang, Y., Li, W., Xue, Y., Hou, X., Yan, J., Cheng, J., Deng, B., McComb, D., Lin, J., Zeng, H., Cheng, X., Irvine, D., Weiss, R., Dong, Y.*, Cholesterol-Amino-Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self-Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice, Advanced Science, (2023).
Chen, S., Huang, X., Xue, Y., Benedicto, E., Shi, Y., Chen, W., Koo, S., Sigeward, D.*, Dong, Y.*, Tao, W.*, Nanotechnology-based mRNA vaccines, Nature Reviews Methods Primers, (2023).
Hou, X., Zaks, T.*, Langer, R.*, Dong, Y.*, Lipid nanoparticles for mRNA delivery, Nature Reviews Materials, (2021).
Zhang, Y., Sun, C., Wang, C., Jankovic, K., Dong, Y.*, Lipids and Lipid Derivatives for RNA Delivery, Chemical Reviews, (2021).
Li, Y., Su, Z., Zhao, W., Zhang, X., Momin, N., Zhang, C., Wittrup, K., Dong, Y.*, Irvine, D*., Weiss, R*., Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity, Nature Cancer, (2020).
Hou, X., Zhang, X., Zhao, W., Zeng, C., Deng, B., McComb, D. W., Du, S., Zhang, C., Li. W., Dong, Y.*, Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis, Nature Nanotechnology, (2020).
Address
Icahn Genomics Institute
Precision Immunology Institute
Department of Immunology and Immunotherapy
Department of Oncological Sciences
Tisch Cancer Institute
Friedman Brain Institute
Icahn School of Medicine at Mount Sinai
1425 Madison Avenue, New York, NY, 10029
Contact information
Email: yizhou.dong@mssm.edu
