Representative Publications
Xue, Y., Hou, X.*, Wang, S., Zhang, Y., Zhong, Y., Kang, D. D., Wang, C., Li, H., Yu, C., Liu, Z., Tian, M., Cao, D., Zheng, Y. Y., Deng, B., Hamon, P., Merad, M. , Dong, Y.*, Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia. Nature Biotechnology (2025).
Li, H., Yu, C., Markovic, T., Nestler, E. J.*, Dong, Y.*, Chemical strategies for brain delivery of genomic therapy. Nature Reviews Chemistry (2025). PMID: 41291238
Kang, D. D., Marks, A., Morla-Folch, J., Dong, Y.*, Brown, B. D.* , Teunissen, A. J. P.*. Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level. Nature Biomedical Engineering, 9, 1591-1609, (2025). PMID: 41102346
Cao, D., Hou, X., Wang, C., Wang, S., Liu, Z., Tian, M., Guo, K., Li, H., Kang, D. D., Zhong, Y., Xue, Y., Yu, C., Deng, B. , Dong, Y.*, Lipid nanoparticles for mRNA delivery in brain via systemic administration. Science Advances 11(33), eadw0730 (2025). PMID: 40802746
Wang, S., Weissman, D.*, Dong, Y.*, RNA chemistry and therapeutics. Nature Reviews Drug Discovery, (2025). PMID: 40659813
Wang, C., Xue, Y., Markovic, T., Li, H., Wang, S., Zhong, Y., Du, S., Zhang, Y., Hou, X., Yu, Y., Liu, Z., Tian, M., Kang, D.D., Wang, L., Guo, K., Cao, D., Yan, J., Deng, B., McComb D.W., Parsons, R.E., Minier-Toribio, A.M., Holt, L.M., Pan, J., Hashemi, A., Kopell, B.H., Charney, A.W., Nestler, E.J.*, Peng, P.C.*, Dong, Y.*, Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nature Materials, (2025). PMID: 39962245
Wang, C., Wang, S., Xue, Y., Zhong, Y., Li, H., Hou, X., Kang, D.D., Liu, Z., Tian, M., Wang, L., Cao, D., Yu, Y., Liu, J., Cheng, X., Markovic, T., Hashemi, A., Kopell, B.H., Charney, A.W., Nestler, E.J.*, Dong, Y.*, Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system, Nature Biotechnology, (2024). PMID: 39587229
Wang, S., Zhang, Y., Zhong, Y., Xue, Y., Liu, Z., Wang, C., Kang, D. D., Li, H., Hou, X., Tian, M., Cao, D., Wang, L., Guo, K., Deng, B., McComb, D. W., Merad, M., Brown, B. D., & Dong, Y.*, Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation. Proceedings of the National Academy of Sciences of the United States of America, 121(22), e2322935121 (2024). PMID: 38771877
Zhang, Y., Hou, X., Du, S., Xue, Y., Yan, J., Kang, D., Zhong, Y., Wang, C., Deng, B., McComb, D., Dong, Y.*, Close the cancer–immunity cycle by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy, Nature Nanotechnology, (2023). doi.org/10.1038/s41565-023-01453-9
Li, W., Zhang, X., Zhang, C., Yan, J., Hou, X., Du, S., Zeng, C., Zhao, W., Deng, B., McComb, D., Zhang, Y., Kang, D., Li, J., Carson, W., Dong, Y.*, Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy, Nature Communications, 12-7264 (2021). PMID: 34907171
Zhao, W., Zeng, C., Yan, J., Du, S., Hou, X., Zhang, C., Li, W., Deng, B., McComb, D.W., Xue, Y., Kang, D.D., Dong, Y.*, Construction of messenger RNA (mRNA) probes delivered by lipid nanoparticles to visualize intracellular protein expression and localization at organelles, Advanced Materials, 2103131 (2021). PMID: 34541724
Hou, X., Zaks, T.*, Langer, R.*, Dong, Y.*, Lipid nanoparticles for mRNA delivery, Nature Reviews Materials, 1-17 (2021). PMCID: PMC8353930
Zhang, Y., Sun, C., Wang, C., Jankovic, K.E., Dong, Y.*, Lipids and Lipid Derivatives for RNA Delivery, Chemical Reviews, 12181-12277 (2021). PMID: 34279087
Li, Y., Su, Z., Zhao, W., Momin, N., Zhang, C., Wittrup, K. D., Dong, Y.*, Weiss, R.*, Irvine, D.J.*, Multifunctional oncolytic nanoparticles carrying therapeutic self replicating RNA eliminate established tumors and prime systemic immunity, Nature Cancer, (2020), https://doi.org/10.1038/s43018-020-0095-6.
Zhang, X., Zhao, W., Nguyen, G.N., Zhang, C., Zeng, C., Yan, J., Du, S., Hou, X., Li, W., Jiang, J., Deng, B., McComb, D. W., Dorkin, R., Shah, A., Barrera, L., Gregoire, F., Singh, M., Chen, D.*, Sabatino, D.E. *, Dong, Y.*, Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing, Science Advances, (2020), DOI: 10.1126/sciadv.abc2315.
Hou, X., Zhang, X., Zhao, W., Zeng, C., Deng, B., McComb, D. W., Du, Shi., Zhang, C., Li, W., Dong, Y.*, Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis,Nature Nanotechnology, 15, 41–46 (2020). PMID: 31907443
Li, B., Zhao, W., Luo, X., Zhang, X., Li, C., Zeng, C., Dong, Y.*, Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency, Nature Biomedical Engineering, 1(5): (2017). PMID: 28840077
Publications
2026
Li, H., Wang, L., Zhong, Y., Guo, K., Xue, Y., Wang, C., Wang, S., Hou, X., Chen, D. S., Liu, Z., Cao, D., Tian, M., Kang, D. D., Mu, X., Deng, B., McComb, D. W., Taouli, B., Brown, B. D. , Dong, Y.*, mRNA-based MRI contrast agent for precise diagnosis of glioma and pseudoprogression. Cell Biomaterials (2026).
2025
Xue, Y., Hou, X.*, Wang, S., Zhang, Y., Zhong, Y., Kang, D. D., Wang, C., Li, H., Yu, C., Liu, Z., Tian, M., Cao, D., Zheng, Y. Y., Deng, B., Hamon, P., Merad, M. , Dong, Y.*, Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia. Nature Biotechnology (2025).
Li, H., Yu, C., Markovic, T., Nestler, E. J.*, Dong, Y.*, Chemical strategies for brain delivery of genomic therapy. Nature Reviews Chemistry (2025). PMID: 41291238
Liu, Z. , Dong, Y.*, AI-powered design accelerates the development of mRNA therapeutics. News & Views. Nature Chemical Biology (2025). PMID: 41238837
Kang, D. D., Marks, A., Morla-Folch, J., Dong, Y.*, Brown, B. D.* , Teunissen, A. J. P.*. Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level. Nature Biomedical Engineering, 9, 1591-1609, (2025). PMID: 41102346
Li, H., Zhang, Y., Zhong, Y., Guo, K., Du, S., Xue, Y., Wang, C., Wang, S., Chen, D. S., Liu, Z., Cao, D., Tian, M., Yu, C., Kang, D. D., Hou, X., Deng, B., McComb, D. W., Thatikonda, S. K., Yen, C.-W.* , Dong, Y.*. Aminophosphonate-Derived lipid nanoparticles enable circular RNA delivery for functional recovery after spinal cord injury. Materials Today (2025).
Guo, K., Cao, D., Marchese-Thomas, L. P. , Dong, Y.*. Antibody Engineering for Receptor-Mediated Transcytosis Across the Blood–Brain Barrier. Bioconjugate Chemistry (2025). PMID: 41031862
Son, J.*, Yoo, H., Park, J., Park, H., Chong, S.-E., Lee, J., Kim, J., Park, E., Kang, S., Ban, J., Song, S., Oh, E., Kwak, H., Kwon, H., Jung, J., Lee, N., Jung, B., Zhang, Y., Kang, D. D., Du, S., Shin, Y. K.*, Dong, Y.* , Jeong, J. U. Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency. Molecular Therapy Nucleic Acids 102697 (2025).
Akalu, Y. T., Patel, R. S., Taft, J., Canas-Arranz, R., Geltman, R., Richardson, A., Buta, S., Martin-Fernandez, M., Sazeides, C., Pearl, R. L., Mainkar, G., Kurland, A. P., Rosberger, H., Kang, D. D., Kurian, A. A., Kaur, K., Altman, J., Dong, Y., Johnson, J. R., Zangi, L., Lim, J. K., Albrecht, R. A., García-Sastre, A., Rosenberg, B. R. , Bogunovic, D.*, An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo. Science Translational Medicine 17 (811), eadx5758 (2025). PMID: 40802739
Yan, Q., Duan, N., Lin, M., Zhang, W., Denton, S., Zhong, Y., Dong, Y. , Rikihisa, Y.*, Development of mRNA–lipid nanoparticle intrabodies against rickettsial infection. Journal of Biomedical Science 32 (1), 76 (2025). PMID: 40797321
Cao, D., Hou, X., Wang, C., Wang, S., Liu, Z., Tian, M., Guo, K., Li, H., Kang, D. D., Zhong, Y., Xue, Y., Yu, C., Deng, B. , Dong, Y.*, Lipid nanoparticles for mRNA delivery in brain via systemic administration. Science Advances 11(33), eadw0730 (2025). PMID: 40802746
Lee, Y., Guo, K., Oh, M., Kim, E., Jeong, Y., Yoon, Y., Choi, Y., Hwang, Y., Byeon, Y., Dong, Y.*, Lee, H.*, Advances in the rational design of ionizable lipids for mRNA therapeutics. Materials Today (2025).
Yousefpour, P., Ghosh, A. R., Chawla, H., Yeung, R., Gregory, J., Si, K., Remba, T. K., Rodrigues, K. A., Melo, M. B., Dye, J., Steichen, J. M., Zhang, Y., Dong, Y., Crispin, M., Schief, W. R., Batista, F. D. , Irvine, D. J.*, Augmented germinal center and antibody responses to HIV Env trimers delivered as transmembrane immunogens by self-replicating RNA. Molecular Therapy (2025). PMID: 40739754
Wang, S., Weissman, D.*, Dong, Y.*, RNA chemistry and therapeutics. Nature Reviews Drug Discovery, (2025). PMID: 40659813
Cui, Z., Liu, T., Bacon, R., Zhao, Y., Everitt, J. I., Yan, J., Chen, L., Huang, J., Wang, H., Dong, Y.*, Jin, V. X.*, Liu, S.-L.*, & Wang, Q.*. Single-dose cathepsin L CRISPR nanotherapy mitigates PASC-like lung damage in hamsters. Nano Research. (2025).
Cao, D., Tian, M., Liu, Z., Guo, K., Peng, J., Ravichandra, A., Ferrell, C., Dong, Y.*, Unlock the sustained therapeutic efficacy of mRNA. Journal of Controlled Release. May 12: 113837 (2025). PMID: 40368188
Cui, Z., Huang, F., Fang, K., Yan, J., Zhang, Y., Kang, D.D., Zhou, Y., Zhao, Y., Everitt, J.I., Hankey, W., Armstrong, A.J., Huang, J., Wang, H., Jin, V.X., Dong, Y.*, Wang, Q.*, SCORT-Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo. Advanced Science (Weinh). May 11:e2417605 (2025). PMID: 40349174
Xue, Y., Wang, C., Li, H., Du, S., Zhong, Y., Zhang, Y., Wang, S., Guo, K., Hou, X., Kang D.D., Liu, Z., Tian, M., Cao, D., Deng, B., McComb, D.W., Markovic, T., Pan, J., Borna, M., Nestler, E.J.*, Peng, P.C.*, Dong, Y.*, Lipid Nanoparticles Enhance mRNA Delivery to the Central Nervous System Upon Intrathecal Injection. Advanced Materials, May 3: e2417097 (2025). PMID: 40317512
Liu, Z., Zhang, Y., Li, H., Guo, K., Tian, M., Cao, D., Kang, D.D., Xue, Y., Hou, X., Wang, C., Wang, S., Zhong, Y., Yu, C., Deng, B., McComb, D.W., Dong Y.*, Furan-Derived Lipid Nanoparticles for Transporting mRNA to the Central Nervous System. Journal of the American Chemical Society Apr 30, (2025). PMID: 40305652
Hou, X., Wang, C., Zhong, Y., Wang, L., Kang, D.D., Lubitz, G., Xue, Y., Liu, Z., Wang, S., Li, H., Tian, M., Cao, D., Guo, K., Deng, B., McComb, D.W., Marron, T., Brown, B.D., Merad, M., Brody, J.D.*, Dong, Y.*, Enhancing antitumor immunity through chemotherapeutic-derived lipid nanoparticle-induced immunogenic cell death and CD40L/Flt3L mRNA-mediated dendritic cell activation. Journal of Controlled Release. Apr 2:113684, (2025). PMID: 40185331
Xue, Y., Hou, X., Zhong, Y., Zhang, Y., Du, S., Kang, D. D., Wang, L., Wang, C., Li, H., Wang, S., Liu, Z., Tian, M., Guo, K., Cao, D., Deng, B., McComb, D. W., Purisic, E., Dai, J., Hamon, P., Brown, B. D., Tsankova, N. M., Merad, M., Irvine, D. J., Weiss, R. & Dong, Y.*, LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment. Nature Communications 16, 2198 (2025). PMID: 40038251
Wang, C., Xue, Y., Markovic, T., Li, H., Wang, S., Zhong, Y., Du, S., Zhang, Y., Hou, X., Yu, Y., Liu, Z., Tian, M., Kang, D.D., Wang, L., Guo, K., Cao, D., Yan, J., Deng, B., McComb, D.W., Parsons, R.E., Minier-Toribio, A.M., Holt, L.M., Pan, J., Hashemi, A., Kopell, B.H., Charney, A.W., Nestler, E.J.*, Peng, P.C.*, Dong, Y.*, Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nature Materials, (2025). PMID: 39962245
Duan, N., Lin, M., Zhang, W., Yan, Q., Chien, R. C., Budachetri, K., Denton, S., Kawahara, J., Lakritz, J., Zhong, Y., Dong. Y., Rikihisa, Y.*, Development of Etf-3-specific nanobodies to prevent Ehrlichia infection and LNP-mRNA delivery in cellular and murine models. Microbiological Research, 292, (2025) 128027. PMID: 39705831
2024:
Huang, F., Li, K., Chen, Z., Gui, Z., Hankey, W., Fang, K., Yan, J., Wang, H., Jin, V. X., Dong, Y., Wang, Q.*, Integrative analysis identifies the atypical repressor E2F8 as a targetable transcriptional activator driving lethal prostate cancer, Oncogene, (2024). PMID: 39613933
Wang, C., Wang, S., Xue, Y., Zhong, Y., Li, H., Hou, X., Kang, D.D., Liu, Z., Tian, M., Wang, L., Cao, D., Yu, Y., Liu, J., Cheng, X., Markovic, T., Hashemi, A., Kopell, B.H., Charney, A.W., Nestler, E.J.*, Dong, Y.*, Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system, Nature Biotechnology, (2024). PMID: 39587229
Wang, S., Zhang, Y., Zhong, Y., Xue, Y., Liu, Z., Wang, C., Kang, D. D., Li, H., Hou, X., Tian, M., Cao, D., Wang, L., Guo, K., Deng, B., McComb, D. W., Merad, M., Brown, B. D., & Dong, Y.*, Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation. Proceedings of the National Academy of Sciences of the United States of America, 121(22), e2322935121 (2024). PMID: 38771877
Yan, J., Kang, D. D., Wang, C., Hou, X., Du, S., Wang, S., Xue, Y., Liu, Z., Li, H., Zhong, Y., Deng, B., McComb, D. W., & Dong, Y.*, LPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities. Nano Research (2024).
Kang, D. D., Hou, X., Wang, L., Xue, Y., Li, H., Zhong, Y., Wang, S., Deng, B., McComb, D., & Dong, Y.*, Engineering LNPs with polysarcosine lipids for mRNA delivery. Bioactive Materials, 37, 86-93 (2024). PMID: 38523704
Xue, Y., Zhang, Y., Zhong, Y., Du, S., Hou, X., Li, W., Li, H., Wang, S., Wang, C., Yan, J., Kang, D. D., Deng, B., McComb, D. W., Irvine, D. J., Weiss, R., Dong, Y.*, LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing. Nature Communications, 15 (1), 739 (2024). PMID: 38272900
2023:
- Swanda, R., Ji, Q., Wu, X., Yan, J., Dong, L., Mao, Y., Uematsu, S., Dong Y., Qian S.*, Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response, Molecular Cell, 83, 18, 3347-3359 (2023). PMID: 37647899
- Chen, S., Huang, X., Xue, Y., Benedicto, E., Shi, Y., Chen, W., Koo, S., Sigeward, D.*, Dong, Y.*, Tao, W.*, Nanotechnology-based mRNA vaccines, Nature Reviews Methods Primers, 3, 63, (2023).
- Zhang, Y., Hou, X., Du, S., Xue, Y., Yan, J., Kang, D., Zhong, Y., Wang, C., Deng, B., McComb, D., Dong, Y.*, Close the cancer–immunity cycle by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy, Nature Nanotechnology, (2023). PMID: 37500773
- Cui, Z., Wang, H., Dong, Y.*, Liu, S.* Wang, Q.*, Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches, Frontiers in Genome Editing, 13, 5, 1231656 (2023). PMID: 37520399
- Wang, C., Wang, S., Kang, D., Dong, Y.*, Biomaterials for in situ cell therapy, BMEMat, 1(3), e12039 (2023).
- Du, S., Yan, J., Xue, Y., Zhong, Y., Dong, Y.*, Adoptive cell therapy for cancer treatment, Exploration, 3, 20210058 (2023).
- Kang, D., Li, H., Dong, Y.*, Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics, Advanced Drug Delivery Reviews, 199, 114961 (2023). PMID: 37321375
- Bohmer, M., Xue, Y., Jankovic, K., Dong, Y.*, Advances in engineering and delivery strategies for cytokine immunotherapy, Expert Opinion on Drug Delivery, 20, 5, 579-595 (2023). PMID: 37104673
- Zhang, Y., Yan, J., Hou, X., Wang, C., Kang, D., Xue, Y., Du, S., Deng, B., McComb, D., Liu, S., Zhong, Y., Dong, Y.*, STING Agonist-Derived LNP-mRNA Vaccine Enhances Protective Immunity Against SARS-CoV-2, Nano letter, 23, 7, 2593–2600 (2023). PMID: 36942873
- Zhong, Y., Du, Shi., Dong, Y.*, mRNA delivery in cancer immunotherapy, Acta Pharmaceutica Sinica B, 13-4, 1348-1357 (2023). PMID: 37139419
- Du, S., Zhang, Y., Li, W., Xue, Y., Hou, X., Yan, J., Cheng, J., Deng, B., McComb, D., Lin, J., Zeng, H., Cheng, X., Irvine, D., Weiss, R., Dong, Y.*, Cholesterol-Amino-Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self-Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice, Advanced Science, 10(11):e2300188 (2023). PMID: 36748274
- Kim, B., Hosn, R., Remba, T., Yun, D., Li, N., Abraham, W., Melo, M., Cortes, M., Li, B., Zhang, Y., Dong, Y., Irvine, D.*, Optimization of storage conditions for lipid nanoparticle-formulated self-replicating RNA vaccines, Journal of Controlled Releases, 353, 241-253 (2023). PMID: 36414195
2022:
- Yan, J., Zhang, Y., Du, S., Xu, C., Li, W., Zhao, Y., Zeng, C., Zhang, C., Cheng, J., Deng, B., McComb, D., Zhao, W., Xue, Y., Kang, D., Cheng, X., Dong, Y.*, Nanomaterials Mediated Co-Stimulation of toll-like Receptors and CD40 for Antitumor Immunity, Advanced Materials, 34-2207486, (2022). PMID: 36121735
- Cui, Z., Zeng, C., Huang, F., Yuan, F., Yan, J., Zhao, Y., Zhou, Y., Hankey, W., Jin, V., Huang, J., Staats, H., Everitt, J., Sempowski, G., Wang, Hong., Dong, Y.*, Liu, S.*, Wang, Q.*, Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection, Nature Chemical Biology, 18-1056 (2022). PMID: 35879545
- Hu, A., Zhu, J., Zeng, C., Lin, C., Yu, J., Liu, J., Lynch, K., Talebian, F., Pan, X., Yan, J., Dong, Y., Li, Z., Bai, X.*, IL-27 Induces CCL5 Production by T Lymphocytes, Which Contributes to Antitumor Activity, The Journal of Immunology, 9-208 (2022). PMID: 35418466
- Liu, J., Zhang, C., Zhang, X., Yan, J., Zeng, C., Talebian, F., Lynch, K., Zhao, W., Hou, X., Du, S., Kang, D., Deng, B., McComb, D., Bai, X.*, Dong, Y.*, Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy, Journal of Controlled Release, 345-306 (2022). PMID: 35301053
- Dong, Y.*, Anderson, D.*, Opportunities and Challenges in mRNA Therapeutics, Accounts of Chemical Research, 1c00739 (2022). PMID: 34979806
- Hong, F.*, Lin, C., Yan, J., Dong, Y., Ouyang, Y., Kim, D., Zhang, X., Liu, B., Sun, S., Gu, W., Li, Z.*, CNPY2 Contributes to Liver Oncogenesis by Promoting UPR-dependent destabilization of p53, Hepatology, 76-1658 (2022). PMID: 34986508
2021:
- Xue, Y., Baig, R., Dong, Y.*, Recent advances of biomaterials in stem cell therapies, Nanotechnology, 33-132501 (2021). PMID: 34933291
- Li, W., Zhang, X., Zhang, C., Yan, J., Hou, X., Du, S., Zeng, C., Zhao, W., Deng, B., McComb, D., Zhang, Y., Kang, D., Li, J., Carson, W., Dong, Y.*, Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy, Nature Communications, 12-7264 (2021). PMID: 34907171
- Wang, C., Zhang, Y., Dong, Y.*, Lipid Nanoparticle–mRNA Formulations for Therapeutic Applications, Accounts of Chemical Research, 1c00550 (2021). PMID: 34793124
- Yan, J., Kang, D., Turnbull, G., Dong, Y.*, Delivery of CRISPR-Cas9 system for screening and editing RNA binding proteins in cancer, Advanced Drug Delivery Reviews, 114042 (2021). PMID: 34767864
- Zhao, W., Zeng, C., Yan, J., Shi, D., Hou, X., Zhang, C., Li, W., Deng, B., McComb, D., Xue, Y., Kang, D., Dong, Y.*, Construction of Messenger RNA (mRNA) Probes Delivered By Lipid Nanoparticles to Visualize Intracellular Protein Expression and Localization at Organelles, Advanced Materials, 2103131 (2021). PMID: 34541724
- Hou, X., Zaks, T.*, Langer, R.*, Dong, Y.*, Lipid nanoparticles for mRNA delivery, Nature Reviews Materials, 6, 1078–1094 (2021). PMID: 34394960
- Zhang, Y., Sun, C., Wang, C., Jankovic, K., Dong, Y.*, Lipids and Lipid Derivatives for RNA Delivery, Chemical Reviews, 121, 12181–12277 (2021). PMID: 34279087
- Yan, J., Kang, D., Dong, Y.*, Harnessing lipid nanoparticles for efficient CRISPR delivery, Biomaterials Science, 06-11 (2021). PMID: 34115079
- Zeng, C., Hou, X., Bohmer, M., Dong, Y.*, Advances of nanomaterials-based strategies for fighting against COVID-19, View, 20200180 (2021). PMID: 34766161
- Chan, C., Du, S., Dong, Y.*,Cheng, X*., Computational and Experimental Approaches to Investigate Lipid Nanoparticles as Drug and Gene Delivery Systems, Current Topics in Medicinal Chemistry, 21(2):92-114 (2021). PMID: 33243123
2020:
- Zhang, S., Shrestha, C., Wisniewski, B., Pham, H., Hou, X., Li, W., Dong, Y., Kopp, B*., Consequences of CRISPR-Cas9-Mediated CFTR Knockout in Human Macrophages, Frontiers in Immunology,11:1871 (2020). PMID: 32973772
- Zeng, C., Hou, X., Yan, J., Zhang, C., Li, W., Zhao, W., Du, S., Dong, Y.*, Leveraging mRNA Sequences and Nanoparticles to Deliver SARS-CoV-2 Antigens In Vivo, Advanced Materials, 2004452 (2020). PMID: 32875709
- Zhang, X., Zhao, W., Nguyen, G., Zhang, C., Zeng, C., Yan, J., Du, S., Hou, X., Li, W., Jiang, J., Deng, B., McComb, D., Dorkin, R., Shah, A., Barrera, L., Gregoire, F., Sign, M., Chen, D*., Sabatino, D*., Dong, Y.*, Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing, Science Advances, 6.34 (2020). PMID: 32937374
- Li, Y., Su, Z., Zhao, W., Zhang, X., Momin, N., Zhang, C., Wittrup, K., Dong, Y.*,Irvine, D*., Weiss, R*.,Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity, Nature Cancer, 10.1038 (2020). PMID: 34447945
- Zeng, C., Zhang, C., Walker, P., Dong, Y.*, Formulation and Delivery Technologies for mRNA Vaccines, Current Topics in Microbiology and Immunology, 10.1007 (2020). PMID: 32483657
- Zhao, P., Zhang, Y., Li, W., Jeanty, C., Xiang, G*., Dong, Y.*, Recent advances of antibody drug conjugates for clinical applications, Acta Pharmaceutica Sinica B, 04-012 (2020). PMID: 33088681
- Zhao, P., Hou, X., Yan, J., Du, S., Xue, Y., Li, W., Xiang, G.*, Dong, Y.*, Long-term storage of lipid-like nanoparticles for mRNA delivery, Bioactive Materials, 5 (2): 358-363 (2020). PMID: 32206737
- Li, W., Chan, C., Zeng, C., Turk, R., Behlike, M., Cheng, X*., Dong, Y.*, Rational Design of Small Molecules to Enhance Genome Editing Efficiency by Selectively Targeting Distinct Functional States of CRISPR-Cas12a, Bioconjugate Chemistry, 18:31(3):542-546 (2020). PMID: 32119776
- Guo, S., Vieweger, M., Zhang, K., Yin H., Wang, H., Li, X., Li, S., Hu, S., Sparreboom, A., Evers, B., Dong, Y., Chiu, W., Guo, P.*,Ultra-thermostable RNA Nanoparticles for Solubilizing and High-yield Loading of Paclitaxelfor Breast Cancer Therapy, Nature Communication, 11:972 (2020). PMID: 32080195
- Li, B., Yan, J., Zhang, Y., Li, W., Zeng, C., Zhao, W., Hou, X., Zhang, C., Dong, Y.*, CRISPR-Cas12a Possess Unconventional DNase Activity that Can Be Inactivated by Synthetic Oligonucleotides, Molecular Therapy-Nucleic Acids, 19:1043-1052 (2020). PMID: 32045875
- Hou, X., Zhang, X., Zhao, W., Zeng, C., Deng, B., McComb, D. W., Du, S., Zhang, C., Li. W., Dong, Y.*, Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis, Nature Nanotechnology, 15(1):41-46 (2020). PMID: 31907443
2019:
- Li, B*., Niu, Y*., Ji, W*., Dong, Y.*, Strategies for the CRISPR-based therapeutics, Trends in Pharmacological Sciences, 41(1):55-65 (2019). PMID: 31862124
- Zhao, W., Hou, X., Vick, O.G., Dong, Y.*,RNA delivery biomaterials for the treatment of genetic and rare diseases, Biomaterials, 217:119291 (2019). PMID: 31255978
- Dong, Y., Siegwart, D. J., Anderson, D.G., Strategies, design, and chemistry in siRNA delivery systems, Advanced drug delivery reviews, 144:133-147 (2019). PMID: 31102606
- Zhang, Y., Zhang, X., Zeng, C., Li, B., Zhang, C., Li, W., Hou, X., Dong, Y.*, Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR), Bioorganic & medicinal chemistry, 27(11): 2187-2191 (2019). PMID: 31005367
- Zhang, C., Zhao, W., Bian, C., Hou, X., Deng, B., McComb, D. W., Chen, X., Dong, Y.*, Antibiotic-derived lipid nanoparticles to treat intracellular Staphylococcus aureus, ACS Appl. Bio Mater., 2(3): 1270-1277 (2019). PMID: 31750420
- Zhang, C., Zhang, X., Zhao, W., Zeng, C., Li, W., Li, B., Luo, X., Li, J., Jiang, J., Deng, B., McComb, D. W., Dong, Y.*, Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer, Nano Research, 12(4):855-861 (2019). PMID: 31737223
2018:
- Zhang, X., Zhang, C., Yang, X., Hou, X., Zhao, W., Benson, D., Yu, J., Dong, Y.*, Design, synthesis and evaluation of anti-CD38 antibody drugconjugate based on Daratumumab and Maytansinoid, Bioorganic & Medicinal Chemistry, 27(3):479-482 (2018). PMID: 30594452
- Li, B., Zeng, C., Li, W., Zhang, X., Luo, X., Zhao, W., Zhang, C., Dong, Y.*, Synthetic oligonucleotides inhibit CRISPR-Cpf1- mediated genome editing, Cell Reports, 25(12):3262-3272 (2018). PMID: 30566855
- Zhang, X., Zhao, W., Li, B., Li, W., Zhang, C., Hou, X., Jiang, J., Dong, Y.*, Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice, Chemical Science, 9(43):8207-8212 (2018). PMID: 30542568 (HOT Chemical Science articles for September)
- Zhao, W., Zhang, C., Li, B., Zhang, X., Luo, X., Zeng, C.,Li, W., Gao, M., Dong, Y.*, Lipid polymer hybrid nanomaterials for mRNA delivery, Cellular and Molecular Bioengineering, 11(5):397-406 (2018). PMID: 30555598
- Luo, X., Zhao, W., Li, B., Zhang, C., Bratasz, A., Deng, B., McComb, D. W., Dong, Y.*, Co-delivery of mRNA and SPIONs through amino-ester nanomaterials, Nano Research, 11(10):5596-5603 (2018).
- Li, B., Zhang, X., Dong, Y.*, Nanoscale platforms for messenger RNA delivery, Wiley Interdiscip Rev Nanomed Nanobiotechnol, e1530. PMID: 29726120
- Li, B., Zeng, C., Dong, Y.*, Design and assessment of engineered CRISPR– Cpf1 and its use for genome editing, Nature Protocols, 13(5):899–914 (2018). PMID: 28840077
2017:
- Guo, S., Li, H., Ma, M., Fu, J., Dong, Y.*, Guo, P*., Size, shape, and sequence-dependent immunogenicity of RNA nanoparticles, Molecular Therapy: Nucleic Acids, 9:399-408 (2017). PMID: 5701797
- Zhang, X., Chen, X., Zhao, W., Zeng, C., Luo, X., Li, W., Li, B., Jiang, J., Dong, Y.*,GlcNAc conjugated atorvastatin with enhanced water solubility and cellular internalization, Bioconjugate Chem, 28(8):2109-2113 (2017). PMID: 28745862
- Zhang, X.,1 Li, B.,1 Luo, X.,1 Zhao, W., Jiang, J., Zhang, C., Gao, M., Chen, X., Dong, Y.*, Biodegradable amino-ester nanomaterials for Cas9 mRNA delivery in vitro and in vivo, ACS Appl. Mater. Interfaces, 9(30):25481-25487 (2017). PMID: 28685575
- Li, B., Zhao, W., Luo, X., Zhang, X., Li, C., Zeng, C., Dong, Y.*, Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency, Nature Biomedical Engineering, 1(5): (2017). PMID: 28840077
- Jiang, C.,1 Mei, M.,1 Li, B.,1 Zhu, X.,1 Zu, W., Tian, Y., Wang, Q., Guo, Y., Dong, Y.*,Tan, X.* A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo, Cell Research, 27(3):440-443 (2017). PMID: 28117345
- Luo, X., Li, B., Zhang, X., Zhao, W., Bratasz, A., Deng, B., McComb, D. W., Dong, Y.*, Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents, Nanoscale, 9(4):1575-1579 (2017). PMID: 28067926
- Luo, X., Wang, W., Dorkin, J. R., Veiseh, O., Chang, P. H., Abutbul-Ionita, I., Danino, D., Langer, R., Anderson, D. G.*,Dong, Y.*, Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo, Biomaterials Science, 5(1):38-40 (2017). PMID: 27921096
2016:
- Li, B.,1 Zhao, W.,1 Zhang, X.,1 Wang, J., Luo, X., Baker, S. D., Jordan, C. T., Dong, Y.*, Design, synthesis and evaluation of anti-CD123 antibody drug conjugates, Bioorganic & Medicinal Chemistry, 24(22):5855-5860 (2016). PMID: 27687970
- Dong, Y., Wang, W., Veiseh, O., Appel, E. A., Xue, K., Webber, M. J., Tang, B., Yang, X. W., Weir, G., Langer, R., Anderson, D. G. Injectable and glucose-responsive hydrogels based on boronic acid–glucose complexation, Langmuir, 21(34):8743-8747 (2016). PMID: 27455412
- Wang, J., Li, B., Zhao, W., Zhang, X., Luo, X., Corkins, M. E., Cole, S. L., Wang, C., Xiao, Y., Bi, X., Pang, Y., McElroy, C. A., Bird, A. J., Dong, Y.*, Two-photon near infrared (NIR-NIR) fluorescent turn-on probe toward cysteine (Cys) and its imaging applications, ACS Sensor, 1(7):882-887 (2016).
- Li, B., Luo, X., Dong, Y.*, Effects of chemically modified messenger RNA on protein expression, Bioconjugate Chemistry, 27(3):849-853 (2016). PMID:2690652
- Li, B.,1 Luo, X.,1 Deng, B., Giancola, D. W., McComb, D. W., Schmittgen, T. D., Dong, Y.*, Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA, Scientific Reports, doi: 10.1038/srep22137 (2016). PMID: 26916931
- Yin, H., Song, C.-Q., Dorkin, R. J., Zhu, L., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., Gupta, A., Bolukbasi, M. F., Walsh, S., Bogorad, R. L., Gao, G., Weng, Z., Dong, Y., Kotelianski, V., Wolfe, S. A., Langer, R., Xue, W., Anderson, D. G. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Nature Biotechnology, 34(3):328-333 (2016). PMID: 26829318
- Dong, Y., Dorkin, R. J., Wang, W., Chang, P. H., Webber, M. J., Tang, B. C., Yang, J., Abutbul-Ionita, I., Danino, D., DeRosa, F., Heartlein, M., Langer, R., Anderson, D.G. Poly(glycoamidoamine) brushes formulated nanomaterials for systemic siRNA and mRNA deliveryin Vivo, Nano Letters, 16(2):842-848 (2016). PMID: 26727632
2015:
- Li, B., Luo. X., Deng, B., Wang, J., McComb, D., Shi, Y., Gaensler, K., Tan, X., Dunn, A., Kerlin, B., Dong, Y.*, An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo, Nano Letters, 15(12):8099-8107 (2015). PMID: 26529392
- Khan, O. F., Zaia, E. W., Jhunjhunwala, S., Xue, W., Cai, W., Yun, D. S., Barnes, C., Dahlman, J. E., Dong, Y., Pelet, J. M., Webber, M. J., Tsosie, J., Jacks, T., Langer, R., Anderson, D. G. Dendrimer-inspired nanomaterials for the in vivodelivery of siRNA to lung vasculature, Nano Letters, 15(5):3008-3016 (2015). PMID: 25789998
2014 and Prior:
- Dong, Y.; Eltoukhy, A. A.; Alabi, C. A.; Kohan, O. F.; Veiseh, O.; Dorkin, R. J.; Sirirungruang, S.; Yin, H.; Tang, B. C.; Pelet, J.; Chen, D.; Gu, Z.; Xue, Y.; Langer, R.; Anderson, D. G. Lipid like Nanomaterials for Simultaneous Gene Silencing and Expressionin vivo, Advanced Healthcare Materials, 3 (9) 1392-1397 (2014). PMID: 24623658
- Dong, Y.; Love, K. T.; Dorkin, R. J.; Sirirungruang, S.; Zhang, Y.; Chen, D.; Bogorad, R., Yin, H., Chen, Y; Vegas, A.; Alabi, C. A.; Sahay, G., Olejnik, K. T.; Wang, W.; Shroeder, A.; Lytton-Jean, A. K. R.; Siegwart, D. J.; Akinc, A.; Barnes, C., Barros, S. A.; Carioto, M.; Fitzgerald, K.; Hettinger, J.; Kumar, V.; Novobrantseva, T. I.; Qin, J.; Querbers, W.; Kotelianski, V.; Langer, R.; Anderson, D. G. Lipopeptide Nanoparticles for Potent and Selective siRNA Delivery in Rodents and Nonhuman Primates, Proceedings of the National Academy of Sciences, 111 (11), 3955-3960 (2014). PMID: 24516150 (Highlighted by SciBX, 2014).
- Dahlman, J. E.; Barnes, C.; Khan, O. F.; Thiriot, A.; Jhunjunwala, S.; Shaw, T. E.; Xing, Y.; Sager, H. B.; Sahay, G.; Speciner, L.; Bader, A.; Bogorad, R. L.; Yin, H.; Racie, T.; Dong, Y.; Jiang, S.; Seedorf, D.; Dave, A.; Singh Sandhu, K.; Webber, M. J.; Novobrantseva, T.; Ruda, V. M.; Lytton-JeanAbigail, K. R.; Levins, C. G.; Kalish, B.; Mudge, D. K.; Perez, M.; Abezgauz, L.; Dutta, P.; Smith, L.; Charisse, K.; Kieran, M. W.; Fitzgerald, K.; Nahrendorf, M.; Danino, D.; Tuder, R. M.; von Andrian, U. H.; Akinc, A.; Panigrahy, D.; Schroeder, A.; Koteliansky, V.; Langer R.; Anderson, D. G. In vivoendothelial siRNA delivery using polymeric nanoparticles with low molecular weight, Nature Nanotechnology, 9 (8), 648-655 (2014). PMID: 24813696
- Eltoukhy, A. A.; Chen, D.; Veiseh, O.; Pelet, J.; Yin, H.; Dong, Y.; Anderson, D. G. Nucleic Acid-Mediated Intracellular Protein Delivery by Lipid-like Nanoparticles, Biomaterials, 35 (24), 6454-6461 (2014). PMID: 24831975
- Gu, Z., Dang, T.T., Ma, M.M., Tang, B.C., Cheng, H., Jiang, S., Dong, Y., Zhang, Y., Anderson, D.G. Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery, ACS Nano, 7 (8), 6758-6766 (2013). PMID: 23834678
- Zhang, Y., Pelet, J.M., Heller, D.A., Dong, Y., Chen, D., Gu, Z., Joseph, B.J., Wallas, J., Anderson, D.G. Lipid-Modified Aminoglycoside Derivatives for in vivosiRNA Delivery, Advanced Materials, 33 (25) 4641–4645 (2013). PMID: 23813808
- Chen, D.; Love, K. T.; Chen, Y.; Eltoukhy, A. A.; Kastrup, C.; Dong, Y.; Whitehead, K. A.; Langer, R.; Anderson, D. G. Rapid Discovery of Potent siRNA-Lipid-Nanoparticles Enabled by Controlled Microfluidic Formulation, Journal of the American Chemical Society, 134 (16), 6948–6951 (2012). PMID: 22475086
- Wang, L-T., Pan, S-L., Chen, T-H., Dong, Y., Lee, K. H., Teng, C-M. DYZ-2-90, a Novel Neo-tanshinlactone Ring-Opened Compound, Induces ERK-Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells, ChemBioChem, 13 (11) 1663-1672 (2012). PMID: 22761044
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Yoon, K.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, E. Y.-H.; Lee, K. H. Antitumor Agents 289. Design, Synthesis, and In VivoAnti-Breast Cancer Activity of 4-Amino-2H-benzo[h]chromen-2-one (ABO) and 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (ATBO) Analogs with Improved Water Solubility, Journal of Natural Products, 75 (3), 370–377 (2012). PMID: 22304236
- Lee, K. H.; Morris-Natschke, S. L.; Qian, K.; Dong, Y.; Yang, X.; Zhou, T.; Belding, E.; Wu, S. F.; Wada, K.; Akiyama, T. Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman’s Herbal Foundation Canon, Journal of Traditional and Complementary Medicine, 2, 6-26 (2012). PMID: 24716110
- Dong, Y.; Morris-Natschke, S. L.; Lee, K. H. Biosynthesis, Total Syntheses, and Antitumor Activity of Tanshinones and their Analogs as Potential Therapeutic Agents, Natural Product Reports, 28, 529-542 (2011). PMID: 21225077 (Selected and abstracted by ChemInform, 2011, 42, 27).
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, K. H. Antitumor Agents 287. Substituted 4-amino-2H-pyran-2-one (APO) Analogs Reveal a New Scaffold from Neo-tanshinlactone with In Vitro Anticancer Activity, Bioorganic & Medicinal Chemistry Letters, 21, 2341-2344 (2011). PMID: 21420855 (Selected and abstracted by ChemInform, 2011, 42, 34).
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, K. H. Antitumor Agents 281. Design, Synthesis, and Biological Activity of Substituted 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogs (ATBO) as Potent In Vitro Anticancer Agents, Bioorganic & Medicinal Chemistry Letters, 21, 546-549 (2011). PMID: 21087859
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Yoon, K.; Wu, P. C.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, E. Y.-H.; Lee, K. H. Antitumor Agents 279. Structure-Activity Relationship andIn Vivo Studies of Novel 2-(Furan-2-yl)naphthalen-1-ol (FNO) Analogs as Potent and Selective Anti-Breast Cancer Agents, Bioorganic & Medicinal Chemistry Letters, 21, 52-57 (2011). PMID: 21147529
- Dong, Y.; Nakagawa-Goto,K. ; Lai, C. Y.; Morris-Natschke, S. L.; Bastow, K. F.; Lee, K. H. Antitumor Agents 278. 4-Amino-2H-benzo[h]chromen-2-one Analogs (ABO) as Potent In Vitro Anticancer Agents, Bioorganic & Medicinal Chemistry Letters, 20, 4085-4087 (2010). PMID: 20542429
- Chou, L.-C.; Tsai, M.-T.; Hsu, M.-H.; Wang, S.-H.; Way, T.-D.; Huang, C.-H.; Lin, H.-Y.; Qian, K.; Dong, Y.; Lee, K.-H.; Huang, L.-J.; Kuo, S.-C. Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents, Journal of Medicinal Chemistry, 53, 8047-8058 (2010). PMID: 20973552
- Dong, Y.; Shi, Q.; Pai, H-C.; Peng, C-Y.; Pan, S-L.; Teng, C-M.; Nakagawa-Goto,K. ; Yu, D.;Liu, Y-N.; Wu, P-C.; Bastow, K.; Morris-Natschke, S. L.; Brossi, A.; Lang, J-Y.; Hsu, J. L.; Hung, M-C.; Lee, E. Y.-H. P. Lee, and Lee, K-H. Antitumor Agents 272. Structure–Activity Relationships andIn Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogs, Journal of Medicinal Chemistry, 53, 2299-2308 (2010). PMID: 20148565 (Highlighted by SciBX, February 25, 2010).
- Dong, Y.; Shi, Q.; Nakagawa-Goto,K. ; Wu, P. C.; Morris-Natschke, S. L.; Brossi, A.; Bastow, K.; Lee, K. H. Antitumor Agents 270. Novel Substituted 6-Phenyl-4H-furo[3,2-c]pyran-4-one Derivatives as Potent and Highly Selective Anti-Breast Cancer Agents, Journal of Medicinal Chemistry, 18, 803-808 (2010). PMID: 20034799 (Reported by NewsRX, Feb 22, 2010).
- Dong, Y.; Shi, Q.; Nakagawa-Goto,K. ; Wu, P. C.; Bastow, K.; Morris-Natschke, S. L.; Lee, K. H. Antitumor Agents 269. Non-Aromatic Ring-A Neo-tanshinlactone Analog, TNO, as a New Class of Potent Antitumor Agents, Bioorganic & Medicinal Chemistry Letters, 19, 6289-6292 (2009). PMID: 19819136 (Selected and abstracted by ChemInform , 2010 , 41, 12-203).
- Dong, Y.; Shi, Q.; Liu, Y. -N.; Wang, X.; Bastow, K.F.; Lee, K.-H. Antitumor Agents 266. Design, Synthesis, and Biological Evaluation of Novel 2-(Furan-2-yl)naphthalen-1-ol Derivatives as Potent and Selective Antibreast Cancer Agents, Journal of Medicinal Chemistry, 52, 3586-3590 (2009) (Highlighted by SciBX, May 21, 2009). PMID: 19425534
- 1.Zhong, Y. W.; Dong, Y.; Fang, K.; Izumi, K.; Xu, M. H.; Lin, G. Q. A Highly Efficient and Direct Approach for Synthesis of Enantiopure β-Amino Alcohols by Reductive Cross-Coupling of Chiral N-tert-Butanesulfinyl Imines with Aldehydes, Journal of the American Chemical Society, 127, 11956-11957 (2005). PMID: 16117531 (Highlighted by SYNFACTS , 2005, 3, 0331; Selected and abstracted by ChemInform , 2005, 37, 01-088).
*, corresponding author; 1, co-first author.
Selected Patents and Inventions (>40)
- Dong, Y.; Li, B. Lipid-like nanoparticles (LLN) and uses thereof, U.S. Provisional Patent application No 62/164,891, The Ohio State University, 2015.
- Dong, Y.; Wang, W.; Appel, E.A.; Veiseh, O.; Webber, M.J.; Tang, B.C.; Xue, K.;Langer, R.; Anderson, D. G. Injectable hydrogels and Uses Thereof, U.S. Provisional Patent application No. 62/137,003, 2015.
- Dong, Y.; Dorkin, R. J.; Langer, R.; Anderson, D. G. Polymer-Lipid Brush and Uses Thereof, U.S. Provisional Patent application No. 62/036,492, 2014.
- Dong, Y.; Anderson, D. G. Lipid formulations for delivery of messenger RNA, U.S. Patent application No. 14/521,161, 2014.
- Dong, Y.; Love, K. T.; Chen, D.; Chen, Y; Zhang, Y.; Vegas, A.; Alabi, C. A.; Langer, R.; Anderson, D. G. Amino acid-, Peptide- and Polypeptide-Lipids, Isomers, Compositions, and Uses Thereof, U.S. Patent application No. 13662002, 2013. (Filed in over 30 countries and regions; Licensed by two companies)
- Dong, Y.; Eltoukhy, A.A., Alabi, C. A.; Yin, H.; Dorkin, R. J.; Chen, D.; Langer, R.; Anderson, D. G. 1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof, U.S. Patent application No. 14267530, 2014.
- Anderson, D. G.; Chen, D.; Dong, Y.; Veiseh, O.; Eltoukhy, A.A.; Yin, H.; Langer, R.; Method for Achieving Intracellular Protein Delivery Using Oligonucleotide Conjugation and Uses Thereof, MIT – 16539, 2013.
- Anderson, D. G.; Dahlman, J. E.; Dong, Y.; Khan, O. F.; Langer, R.; Degradable and Non-Degradable Dendrimer-Based Lipidoids and Uses Thereof, MIT – 16054, 2013.
- Zhang, Y.; Heller, D. A.; Pelet, J.; Dong, Y.; Synthetic Sugar-based Lipids and Uses Thereof, MIT – 15369, 2012.
- Shroeder, A.; Dong, Y.; Stark, W. J.; a Water Treatment Device, MIT – 14856, 2011.
- Lee, K. H.; Dong, Y.; Bastow, K. Nakagawa-Goto,K.; Lee, E. Y.-H. 4-Amino-2H-pyran-2-one Analogs as Anticancer Agents; Patent No. WO 2012061012, 2012.
- Lee, K. H.; Dong, Y.; Shi, Q.; Bastow, K. Substituted FNO (2-(Furan-2-yl) naphthalen-1-ol) Derivatives as Anti-cancer Agents; Patent No. WO 2010080414, 2011.
- Lee, K. H.; Dong, Y.; Shi, Q.; Bastow, K.; Wu. P. C. Substituted AFPO (6-aryl-4H-furo [3,2-c]pyran-4-one) Derivatives as Anti-cancer Agents; Patent No. WO 2010080415, 2010.
- Lee, K. H.; Dong, Y.; Bastow, K. Nakagawa-Goto,K. Novel 4-amino-2H-benzo[h]chromen-2-one Analogs as Anti-Cancer agents; U.S. Provisional Patent application No. 61/317,983, 2010.
- Lee, K. H.; Dong, Y.; Shi, Q.; Bastow, K. Neo-tanshinlactone Analogs as Potent and Selective Anti-breast Cancer Agents; U.S. Provisional Patent application No. 61/243,731, 2009.
- Xu, M. H.; Lin, G. Q.; Zhong, Y. W.; Dong, Y. Process for Preparation of Chiral Amino Alcohols and Derivatives via Cross-coupling Reaction. Faming Zhuanli Shenqing Gongkai Shuomingshu (China Patent), 2005, CN1709865.